Nystatin
Class: antifungal – polyene
Indications: fungal infections – topical, oral, gastrointestinal, vaginal
Adverse reactions: less common: nausea, vomiting, diarrhoea (at high doses), local irritation
| Dosing: | |
|---|---|
| oral: | (not absorbed orally) |
| oral candidiasis: | 100,000 units (1 mL) 4 times a day usually for 7 days |
| gastrointestinal candidiasis: | 500,000 to 1,000,000 units 3 times a day |
| subcut: | not available |
| rectal: | not available |
| topical: | apply 2 to 3 times a day |
| vaginal: | insert 5 g of cream once or twice a day |
Syringe driver: not available
Mechanism of action: increases fungal cell membrane permeability
Notes:
- administer dose on the tongue or in the buccal cavity and hold in the mouth for as long as possible before swallowing
- continue treatment for 48 hours after resolved
- if infection is severe or recurrent use a systemic antifungal e.g. fluconazole