Molaxole™

(Macrogol 3350, sodium chloride, sodium bicarbonate, potassium chloride, potassium acesulfame)

Class: laxative – osmotic

Indications: constipation including faecal impaction

Contraindications/cautions: intestinal obstruction or perforation, ileus and severe inflammatory conditions of intestinal tract eg Crohns, cardiac disease (contains sodium and potassium); monitor for fluid imbalance

Adverse reactions: less common: abdominal distension and pain, nausea

Metabolism/clearance: not absorbed

Interactions: few as not absorbed – may affect the absorption of some drugs

Dosing:
Movicol™, Lax-sachet™:
constipation 1 to 3 sachets per day
faecal impaction 8 sachets per day taken within 6 hours for a max. of 3 days. If cardiovascular problems, do not take more than 2 sachets over any 1 hour
  • Each sachet should be dissolved in 125 mL of water. For faecal impaction dissolve 8 sachets in 1 L of water
Movicol-HalfTM:
constipation 1 to 6 sachets/day
faecal impaction 16 sachets/day taken within 6 hours for a max. of 3 days If cardiovascular problems, do not take more than 4 sachets over any 1 hour
  • Each sachet should be dissolved in 60 mL of water

Mechanism of action: osmotic action in the gut to increase liquid content of stools but with no net loss of sodium, potassium or water

Onset: faecal impaction: most cleared after 3 days

Notes:

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