Miconazole
Class: antifungal – imidazole
Indications: fungal infection – topical, oral, GI, vaginal
Contraindications/cautions: hepatic impairment
Adverse reactions: common: oral gel – GI upset; less common: oral gel – hepatitis, topical/vaginal- burning, itching
Metabolism/clearance: metabolised by the liver
Interactions: Oral gel/vaginal preparations (absorption is likely)
- decreased clinical effect of amphotericin may occur with miconazole
- may affect INR of patients taking warfarin. Monitor even if only using oral gel
| Dosing: | |
|---|---|
| mouth (topical): | Oral gel 20 mg/g – Use 2.5 mL (50 mg) 4 times a day for 7 days |
| subcut: | not available |
| rectal: | not available |
| topical: | apply twice a day |
| vaginal: | use at night for 7 nights |
Syringe driver: not available
Mechanism of action: increases fungal cell membrane permeability
Oral gel: place half a measuring spoonful (2.5 mL) on tongue and hold in mouth for as long as possible before swallowing